Riobard

Well of course there is a dose response effect. This has been known since early PrEP trials. Cohorts taking PrEP are better protected whether they are subgroups within randomized control trials or consist of individual state populations. New York is closest to drug assignment while West Virginia more approximates placebo. You wouldn’t have needed Sullivan’s The Lancet paper to substantiate that the lower uptake among the cluster of 10 states with poorest need:get ratio results in poorer infection rate outcomes, given that the overall national “get”, access to PrEP, among those deemed at risk had risen over a decade to only 26%. Sullivan’s group reveals a “modest” [sic] 10-year national reduction in HIV infection deemed attributable to PrEP rollout and TasP combined. The small reduction per capita is downplayed, understandably, because the point of the analysis was to position the PrEP advocacy argument in the context of funding cut threats. You want to be equitable across regions but, more importantly, increase the numbers of at-risk folks acquiring the protection. People starting on PrEP also get tested, and subsequently more regularly. Catching seroconversions adds to the numbers streamed into TasP, the second essential prong for reducing case incidence. Case reduction is not statistically significant at the per 100K level; it’s merely a drop of 2.4 cases. It only approaches significance at about a denominator threshold of 1,600,000. It’s nothing short of naïve to not assume that a substantial proportion of hook-up app users is not represented within the numerical majority of HIV-negative and sexually active, for whom PrEP is indicated but not consumed.

No. You're welcome. But any lace is usually viable if you sanely know what to do with such a resource.

This is a challenge to rank globally because there is no dearth of financially disadvantaged young men pressed to trade off overall biological and sexual health in trying to make ends meet.

Whose boundaries could apparently use some gerrymandering.

Let’s clean up the vowels. It’s Joey, to whom the Johnnies Jacky off.

Cute. Seriously trains at FitWhey afternoons. Very fluent English judging by socials including YouTube channel.

If I have this right technically, this wording sounds off. It’s a rolling migratory year reset early August 2026, if counting back 95 days from your recent departure. Not a calendar year reset in which your next 90 days entry privilege can commence this January, or Easter, or Sampa Pride, etc. If you return next summer also be prepared to pay a fine of 100 reais for each of the 5 overstay days unless perhaps they kindly predetermined the lesser amount and it’s recorded in your file.

The exemption for Yellow Fever vaccination for travellers from Brazil to Colombia was actually (unbeknownst to me) applied on Oct 29th, 2024 and reiterated on Apr 3rd of this year, in spite of a substantial uptick in cases within Colombia. I just plunked my certificate down with everything else when checking in on an Avianca business class flight in February and nothing was said about it. If upon airline check-in they are not up to speed and deny you boarding, an unlikely scenario, you would be advised to produce the evidence by searching the Ministerio de Salud y Protección Social circular externa 018 de 2024 or 012 de 2025.

It’s a typo … the party is D69, but would have liked more seats. He is getting the first crack forming a coalition.

Well seems like Day Mori opens his act with the declaration it’s time to make new friends. While Night Mori is a little bitch who channels the cad in Abracadabra.

But everybody has to start somewhere.

You didn’t oblige his request. Your funeral.

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These days you will still have to navigate the application online for the consular visa version and I think in-person steps are less available, if at all. If you search “Itamaraty San Francisco” you will see that the consular version (VIVIS) is about $100 more than the e-visa. The instructions also stipulate that your first upcoming trip must be definitively planned, in contrast to the e-visa format with entry open-ended.

It was a large gathering. Always many moving parts in such contexts. It is a challenge to apply the type of social lubrication that might otherwise precede a favour request upon discovering an opening to a particular niche resource. It was not heavy-handed importuning. When you disclose your occupation it is wise to have a few light quips to employ when a recipient of such information refers to some aspect of it. If somebody said to the physician they see as conventionally attractive “It’s been ages since I’ve had a decent digital rectal exam” the physician with social skills might reply “It’s been a while since I’ve been offered dinner first.” The physician with poor skills, not open not extroverted not conscientious a temperament, might say something like “Because it’s in your dreams.” An intentional putdown. Asking for the referral was not a putdown. A quip that intends to embarrass is a putdown and neither party can easily come back from it. The magician is not likely subsequently seeking external appraisal of his behaviour. What he couldn’t pull out of his hat is a social grace even if he perceived that the question directed to him was somewhat of an imposition and with premature timing. Sure, perhaps the OP shoulda coulda have deferred the ask. After all, his critics, when in heavily populated social contexts and upon discovering the trade present, typically expend hours in sensitive social lubrication prior to deigning to ask the price of a fuck. The parallel is that you count on others to handle you with equanimity in face-to-face settings. Such is my Emily post.

Dancer.

You already know the solution does not lie in the hair of the doggie style. The answer lies in putting what’s before you behind you.

The friend of your friend is your enema.

You haven’t seen 28 Days, Weeks, Years Later film series? Exile can be a succession bump. In addition to the cocaine one.

More likely a cocaine line in new digs Downturn Abbey.

Glad you’re seronegative and relieved but the story has an abrupt ending considering you were tested due to having been deemed at risk for infection. You must not be taking PrEP because you’d have been already required to determine HIV status regularly. Whether or not you ponied up cash for a clinical procedure you should have been informed about HIV prophylaxis options. I simply want to flag it because I’m not sure what your risk factors are or your degree of awareness for PrEP eligibility going forward.

No I haven’t, not in 11 years of several trips and countless fee-for-service appointments. I once mistakenly underpaid on one occasion by 20% the agreed amount to a guy at his place and he politely texted me later. He was correct as I knew exactly how much I had obtained and the balance I held. I had made it clear the amount I proposed would be in USD or BRL. I blame it on my rare use of US bills … why can’t that treasury get its act together and find some denomination dye? I was mortified. I arranged to have it physically delivered to him, with his permission to address it to him at his building, quite a hike even for an enthusiastic walker like me if I was to have repeated the trek, along with a generous tip consisting of reais to have available to him outside of exchange requirements. Had it been an outcall I’d have had to make different compensatory arrangements. Not that some don't coyly and sweetly put their palms together prayerfully if they witness you sliding their pay off a larger array of notes. I try to remember to avoid display.

Reports of traffic disruption having occurred in the southeastern city region may be overblown if not inaccurate. I think that main route vehicular traffic may be now normalized even where the greatest impacts in the northern zone were. Fallout from yesterday’s flashpoint in terms of disruption in conventional tourism zones may be negligible at face value.

I think it’s day to day following yesterday’s ‘war zone’ up near the main airport. I wonder about residual vehicular traffic blockades posed by one side of the belligerents: the alleged crime faction, that I believe were quite disruptive as an alleged retaliatory measure yesterday, including areas far from the shootout phenomenon. Of course this does not rule out the possibility of police-initiated barricades. At the very least, I would want to be familiar with Metro and Supervia rail options for contingency planning. I assume that the VLT light rail transit, a fairly limited circumscribed area relatively speaking, as well as BRT long haul trans-city bus routes could be comparatively more subject to blockades at a traffic flow structural level. These blockades apparently consist of dozens of buses commandeered (or leased?) by the civilian belligerent category. Those here with boots on the ground will know more. It’s all slowing my roll with respect to planning a trip in the upcoming weeks using up a relatively small amount of allocated visa-dependent days left over prior to my migratory year reset. Likely Europe instead now.

I assume you are basing the first 90% on an estimated percentage of circulating virus that would bypass the mutation. I haven’t drilled down too much but I think the ratio of R5-tropic strain (that which would be preferable in terms of infection escape for the relevant mutation discussed) to X4-tropic strain is deemed to be about 85:15, but X4 is more aggressive? So a lot of moving parts. If one applies the strain proportionality factor to the usually referenced transmission risk estimates that exist outside of consideration for the mutation protective factor, then the degree to which event risk, based on the mutation, for receptive anal (RAI) is reduced to about twice the risk for insertive anal (IAI). Accordingly, it is possible to compare and contrast the volume of true risk events that corresponds to arbitrary probability percentages of infection because number of events is key in infection potential over time. For example, in separate sexual position based calculations about 49 RAI events and 510 IAI events, respectively, for a 10% probability of infection. Escaping infection with the mutation is, as established, not due to absolute immunity but is predominantly due to not having enough sex for breakthrough infection, adjusted for sexual position. The notion of added protection equivalent to condom use is appropriate. The above factors might be considered for risk tolerance and subsequent choice of prophylaxis. Notwithstanding that I use condoms for bacterial STI prevention, I use them as well as PrEP for IAI HIV prophylaxis. It follows that in my case, if unambiguously possessing the mutation, I would certainly continue both condom use and PrEP for RAI. YMMV regarding tolerance and caution.