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belkinDC

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Posts posted by belkinDC

  1. Hi all,

    I'm currently planning a trip to Brazil over New Year's. Thus far I just have my main plane tickets booked; I'm arriving in SP a few days after Xmas and leaving about two weeks later out of GIG/Rio. I had been planning to just spend a few nights in SP before heading to Rio for New Year's and the remainder of my time there.

    But, looking now at Airbnb (and hotel) prices in Rio over NY, it seems it's probably not the best time to visit for someone who isn't particularly interested in their NY festivities. The easiest option is just to stay in SP until 1/3 or 1/4, but I've already spent plenty of time in SP (including 9 nights in late Sept) and wondering if this might be a good opportunity to broaden my Brazilian horizons a bit (which has been limited to Rio/SP thus far; this will be my 6th trip, the first having been in Aug 2019).

    Does anyone have recommendations? I'm in my mid 30s, decent shape, American, don't speak a ton of PT but enough to get buy with GPs, and don't drink or do hard drugs (another reason I'm thinking NYE in RJ might be a skip for me). I've previously wanted to visit POA but recent reports from the city aren't too promising. Another option that a local I met in Lagoa recommended (not necessarily for NYE) is Buzios in RJ state, but that looks more like a destination to perhaps take a guy to once you've already set something up. 

    Anyone have ideas, especially if you've spent NYE there in the past yourself? Is Rio worth taking a 2nd look and just biting the bullet on the higher prices (they aren't necessarily a deal killer for me, but just giving me a bit of sticker shock based on what I've paid on other trips)? 



     

  2. On a recent trip (Sept 2022) in Rio, I took the advice found on a Google review of the TIM store at Shopping Rio Sol and it worked flawlessly:

    https://goo.gl/maps/mDRGDEKmKn2oDq4x7

    "* TRAVELER ADVICE * Avoid the TIM store on the ground floor (they try to sell you something extremely expensive) and straightly head to the 3rd floor! Buy a SIM card for R$ 10 at the C&A (yes, it sounds weird but just ask for “chip”) and head back to the TIM store (3rd floor!!). Tell the people you want to charge it with data and they firstly help you activate your SIM card and secondly sell you data against a fair price. We took 5GB (valid for 180 days) for R$ 50 and they helped us charging it on the phone. Super friendly people and we were lucky not experiencing what the other reviews are describing. Good luck!"

    The C&A store where I bought the chip is on the same level (3rd) as the TIM store. There was a friendly employee there who spoke great English who helped me get it activated over the phone with my passport info, and then they topped me up with BRL 50 for the 6 month plan. I'll be back in a few weeks and see if the plan is still active, but it worked throughout the duration of my 2 weeks in Brazil for that trip.

    From what I can gather, someone who speaks Portuguese or has a friend who does could probably replicate this process just by buying a TIM chip from a street vendor and then "recharging" at one of the many places that offer this service after you have activated it. The TIM store employee helped me to navigate the activation phone tree menu (which was in Portuguese naturally) to get to an English speaking activation agent who took down my passport info. That being done, they took my payment for the 50 BRL top-up but I think that can be done at many locations throughout Brazil and not just at TIM stores.

    Edit: Looks like the recharge can be done online with Xoom, PayPal's money transfer service: https://www.xoom.com/brazil/mobile-reloads/tim

  3. On 11/23/2022 at 1:04 PM, Tomtravel said:

    Hornet has more guys then grindr. I have met many guys in the airbnb in Istanbul center (affordable local hotels are not visitor friendly). Small terrace and view of the Bosporus strait. One really hot and fit guy liked older guys with bold head (I am), well I was happy to fulfill his fantasy. One guy was probably a thieve - he was nervous and strange, next day I realised my cc is gone, not sure when and how he managed. I saw in the banking app purchase attempts in the same evening.

    what area do you prefer to book Airbnbs in Istanbul? A few months ago I stayed for 3 nights at an Airbnb that was just north of Tarlabasi Blvd, a few blocks west of Aquarius, and it was quite a bad area. Although the price was certainly right at about $33/night total with a large terrace. It was just a 5 minute walk to Istikal and I didn't end up having any problems, but it demonstrated to me how rapidly things can shift block by block in that city...

  4. 12 minutes ago, maump said:

    I did an Agoda reservation to holiday in express, then tried to get the points at the front desk, they said no, you must book thru us.  I said you the rate at Agoda was 15$ cheaper, they said call the hotel, tell them, they will verify it and match at the hotel.  I did that next time it worked.  no mention of 54x points.  

    Nice! It looks for this official “guarantee” with the additional points you have to submit the claim centrally via IHG rather than through the individual hotel (although good to know individual hotels can also price match which is probably easier to deal with than IHG)

  5. 10 hours ago, speedoo1 said:

    The rates I paid in July was around 50 USD/night - even cheaper if you prepay with an OTA (but obviously no IHG points then); just look up the hotel in Google map to find the OTAs with lowest rates. I don't like the exchange rates applied by the hotel when converting from USD to COB and then again by my credit card when converting COB to my my currency, hence, I found the OTA rates considerably cheaper.

    I can’t vouch for the ease of navigating the process as I’ve never done it, but theoretically IHG will match OTA rates due to their “best price guarantee” when booking through IHG direct channels. Maybe of use if you find yourself in this situation regularly. https://www.ihg.com/content/us/en/customer-care/best-price-guarantee

  6. 6 hours ago, Mavica said:

    So many choices.  For me, from Tampa, Florida USA to BKK in November, assuming a visit of 2 weeks, airfare is approx. US$1,700 r/t with a travel time of 30 hours.  Ouch!  Tampa > Medellin?  Approx. US$600/8 hours.  Rio?  US$1,200/13 hours.  Santo Domingo:  approx. US$600/6 hours.  Prague?  US$920/16 hours.  

    For Medellin from Tampa, you could also drive to Orlando and fly direct on Spirit… did a quick search and they have direct flights MCO-MDE in Nov from $460 roundtrip with all the “bundled” stuff included (checked bag, carryon, priority boarding etc). Potentially cheaper depending how light you pack. I know people rag on Spirit but for a sub-4 hour flight I personally wouldn’t hesitate.

  7. 25 minutes ago, Slvkguy said:

    The Biden Administration is clearly responsible for the American failure re: monkeypox.

    Perhaps I was too quick to say Congress was at least too much to blame ;) - even though I do think they were very shortsighted re: funding for Jynneos and other MCMs.

    The Biden admin absolutely have poorly played the imperfect hand they were dealt.

  8. 1 hour ago, Mavica said:

    Strategic supplies of Smallpox vaccines and the relatively recent Jynneos vaccine (with a cross use for Monkeypox) have been underfunded for decades.

    That's precisely my point. Yes - nobody knew that Monkeypox would emerge in late Spring 2022 and failed to prepare for that precise eventuality. But the risk of a smallpox attack - or some other orthopoxvirus emergence -- has long been a known risk. As the Politico articles notes, I should rather have said over two decades rather than over a decade that the need to stockpile smallpox vaccines has been a known need. 

    I am not blaming Biden or his Administration exclusively but also and at least as much the US Congress for failing to properly fund our stockpile of medical countermeasures.

    1 hour ago, Mavica said:

    And given the focus on COVID the past couple of years I'll suggest there was an understandable preoccupation with responding to that pandemic ... by national leaders.

    I would suggest that if anything Congress failed to learn the lessons of COVID and makes our lack of preparation for monkeypox even more frustrating... when the shit hit the fan and tons of the PPE and ventilators that we had in the Strategic National Stockpile were found to be unusable, due to years of underinvestment and failing to maintain the stockpile, it should have been a wakeup call.

    Out of the 6 trillion or so spent on COVID-response writ large, they couldn't have found a few billion (or tens) here or there to beef up the procurement and R&D of biodefense medical countermeasures?
     

    1 hour ago, Mavica said:

    President Biden has been in office less than 2 years, so placing blame at his feet for a shortage of Smallpox or the additional vaccine which was approved 9 months after his ascent to the Presidency, is misplaced.

    As I said, I place at least as much blame on Congress. And not to nitpick, but it was approved 16 months before his inauguration rather than 9 months after.

     

    1 hour ago, Mavica said:

    Segments of the gay community can help to substantially slow the spread of Monkeypox.

    No argument from me on this point. Behavior modification should absolutely be part of the solution, and I think the decision of certain event/party planners to go through with big gatherings despite the risk and lack of vaccines was reprehensible.

  9. 43 minutes ago, belkinDC said:

    The re-emergence of an orthopoxvirus has in fact been contemplated and planned for by the US federal government for over a decade, which is why there is/was a stockpile of Jynneos and ACAM. At one point we had 20 million doses of Jynneos in the stockpile, which the government let expire without replacing them. That is indeed a failure and we would have been much better prepared for this outbreak if the stockpile had been maintained at those levels.

    More on this point from Politico:

    https://www.politico.com/news/2022/08/18/u-s-officials-knew-for-years-they-did-not-have-enough-jynneos-vaccine-00052694

    Before monkeypox outbreak, U.S. officials knew for years they didn't have enough of key shot

    A vial of the Jynneos monkeypox vaccine sits on a table at a pop-up vaccination clinic opened today by the Los Angeles County Department of Public Health at the West Hollywood Library.
     

    The Strategic National Stockpile was supposed to have about 120 million Jynneos doses, enough for 60 million people, | Mario Tama/Getty Images

    By ERIN BANCO and HELEN COLLIS

    08/18/2022 03:31 PM EDT

    Updated: 08/18/2022 06:26 PM EDT

    Officials said the Strategic National Stockpile did not have enough Jynneos doses for a potential smallpox outbreak because of a lack of resources.

    Top U.S. health officials have known for years that the country’s Strategic National Stockpile did not have enough doses of a smallpox vaccine that is now key to the monkeypox fight, according to three former senior officials and a current official working on the monkeypox response.

    The U.S. has stockpiled Jynneos, the vaccine by Bavarian Nordic, which is also being used to combat monkeypox.

    The U.S. never had the money to purchase the millions of doses that experts felt were necessary, the officials said. Now, that shortfall is hampering efforts to contain the growing monkeypox outbreak, one in which the Biden administration has come under fire for failing to deliver enough vaccine for the millions of people at risk.

    “Every time I meet a member of Congress, I let them know what the need is,” said Dawn O’Connell, head of the Administration for Strategic Preparedness and Response, in an interview. “The SNS … has been chronically underfunded. We need to get this SNS fully funded and stocked against what we think the next threats are.”

    The Strategic National Stockpile was supposed to have about 120 million Jynneos doses, enough for 60 million people, said the officials who were granted anonymity to discuss sensitive government matters. Jynneos was stockpiled as an alternative to ACAM 2000, a different vaccine that is not suitable for people who are immunocompromised. Prior to 2019, the U.S. had just 20 million doses. In 2020, the U.S. purchased just over 1 million doses to replenish expired vaccine.

    Paul Chaplin, CEO of Bavarian Nordic, told POLITICO on Thursday that after the vaccine received approval from the Food and Drug Administration in 2019, the U.S. stockpile requirement called for the protection of 66 million at-risk Americans. That meant about 132 million doses of the Jynneos shot were needed for people who cannot receive ACAM 2000 in the event of a smallpox outbreak.

    “That’s people [who] are vulnerable who shouldn’t really receive first and second generation vaccines,” Chaplin said.

    An official at the Department of Health and Human Services suggested the 120 million dose figure was higher than the government threshold but did not dispute that the Jynneos stockpile level was below what it should have been, and declined to provide what the SNS requirements actually say.

    The senior officials who spoke to POLITICO said the requirements for the stockpile — levels set in part by HHS — often shift and are, at times, outdated. For example, one former senior official said the department kept two numbers on hand — the number of doses the stockpile could afford to purchase and the number of doses that were actually needed to distribute to a certain population. The number of Jynneos doses the government could afford as of 2019, that official said, was around 40 million. But money for Jynneos shots competed with funding for more pressing priorities and threats the administration perceived as more likely.

    “That’s not preparedness,” said the former senior health official. “It’s like telling the military … you have a requirement for 100 airplanes, but we’re only gonna give you 10 because that’s all we can afford. And then we have to fight. Good luck.”

    Since the Biden administration assumed office, there have been ongoing discussions within the ASPR about adjusting the requirement levels and about how to get additional funding to help ramp up supply of critical medicines and shots.

    In November 2021, senior officials from HHS and the Centers for Disease Control and Prevention held a meeting to discuss responses to a potential smallpox outbreak. Officials there spoke about the Jynneos shot and noted many doses had previously expired. They planned to ask Congress for additional funding to shore up supply, according to one of the former officials who attended the meeting.

    “There was a push after that to get hard, concrete numbers and budget numbers because they didn’t want to report … this huge gap [in supply] back to the White House,” one of the officials said.

    In May of 2021, POLITICO reported that the Biden administration rerouted $2 billion from the SNS to help handle the surge of unaccompanied migrants at the border. In its most recent budget request, ASPR asked for $975 million in funds for the stockpile, about $130 million more than was enacted in 2022.

    “We all saw what happened in 2020 when the PPE we expected to be there wasn’t there. I think Congress felt that acutely as well when their constituents were searching for things,” O’Connell said. “So it is really important for me to use that as a critical example of why we need to move forward and make sure the SNS is well funded against the current material threats.”

  10. 12 hours ago, Mavica said:

    Just who is it, which government worldwide anticipated, the appearance of Monkeypox?  Biden?  Ignorant to suggest that, by anyone.  Listen, many gays aren't old enough to have lived through HIV/AIDS.  Stop the dangerous behavior and the infections will not spread as quickly.  We are responsible for our health, not the "government."

    The re-emergence of an orthopoxvirus has in fact been contemplated and planned for by the US federal government for over a decade, which is why there is/was a stockpile of Jynneos and ACAM. At one point we had 20 million doses of Jynneos in the stockpile, which the government let expire without replacing them. That is indeed a failure and we would have been much better prepared for this outbreak if the stockpile had been maintained at those levels.

  11. 9 hours ago, scott456 said:

    I think one of the problem is, the driver accepts your ride request but doesn't really want to go to your destination (not far enough, or not on his way home).  So he just sits idle until you give up and cancel it (and pay a cancellation fee)

    My understanding is that the driver is not shown what your destination is until they actually pick you up (or at least that’s how it used to be on Uber) because they wanted to prevent precisely that behavior. 

    FWIW I used Uber in CDMX multiple times per day on a 10 day trip about a year ago without any major issues. But I’m curious to hear @Mavica’s fraud concerns knowing that he has much more experience in the country.

  12. New York Times
    Biden Administration to Allow New Injection Method for Monkeypox Vaccine

    The approach — injecting one-fifth of the current dose into the skin instead of a full dose into underlying fat — would help stretch out the nation’s limited supply of vaccine.

    By Sharon LaFraniere and Noah Weiland

    Aug. 8, 2022, 9:43 p.m. ET

    WASHINGTON — The Biden administration has decided to stretch out its limited supply of monkeypox vaccine by allowing a different method of injection that uses one-fifth as much per shot, according to senior administration officials familiar with the planning.

    In order for the Food and Drug Administration to authorize so-called intradermal injection, which would involve injecting one-fifth of the current dose into the skin instead of a full dose into underlying fat, the Department of Health and Human Services will need to issue a new emergency declaration allowing regulators to invoke the F.D.A.’s emergency use powers. That declaration is expected as early as Tuesday afternoon.

    The move would help alleviate a shortage of vaccine that has turned into a growing political and public health problem for the administration.

    The administration has faced a barrage of criticism that it was too slow to ship vaccine that was ready for use to the United States from Denmark, where it was manufactured, and too slow to order that bulk vaccine stocks be processed into vials after the disease first surfaced here in mid-May.

    In less than three months, more than 8,900 monkeypox cases have been reported. The disease spreads primarily through skin-to-skin contact during sex among gay and bisexual men. Federal officials are concerned about both the current infection rate and the risk that the disease could spread to other parts of the population.

    Even though it invested more than $1 billion in developing the two-dose vaccine known as Jynneos that works against both monkeypox and smallpox, the government has only 1.1 million shots on hand. It needs about three times as many doses to cover the 1.6 million to 1.7 million Americans who, according to the Centers for Disease Control and Prevention, are at high risk of contracting monkeypox.

    Federal health officials said last week that so far, they have distributed about 600,000 doses of the vaccine to state and local jurisdictions.

    The Department of Health and Human Services last week issued a broader public emergency declaration that allowed the federal government to more easily allot money and other resources to fight the virus.

    Research on intradermal injection of the monkeypox vaccine is essentially limited to one study. It showed that when the vaccine was injected between skin layers, it induced an immune response comparable to that from a standard injection into the fat underneath the skin. Federal officials have consulted with a variety of outside groups about switching to the intradermal injection approach, including the Infectious Diseases Society of America, according to people familiar with the talks.

    Some outside experts have criticized the data backing up the method for monkeypox as too thin and narrowly focused. The government’s decision to go with it is heavily based on a 2015 study that was sponsored by the National Institutes of Health.

    Dr. John Beigel, an N.I.H. associate director of clinical research who has briefed federal health officials and the World Health Organization, said that switching to the intradermal method was a better option for preserving vaccine than administering just one of the two recommended doses, as some jurisdictions now do. One shot does not prompt nearly as strong an immune response as two, he said.

    “The upside is you can stretch out doses,” said John P. Moore, a virologist at Weill Cornell Medicine. “The downside is, if you cut it too far or take too many liberties, you reduce the efficacy. And how are you going to know that? It’s educated guesswork.”

    The intradermal method can be complicated for vaccinators, who must guide a needle into a thin space. If a vaccinator goes too deep and inserts the dose into fat, the patient might not receive enough vaccine, experts say. But if the needle is not inserted far enough, some of the vaccine could leak back out.

    Such shots typically induce more redness and swelling, but are less painful than a standard injection, the 2015 study showed.

    They have previously been used in polio vaccination campaigns, for rabies and with tuberculosis skin tests.

    The National Institutes of Health had planned further studies into how well such shots work with the monkeypox vaccine, but the results were not expected until the late fall or early winter. Over the weekend, top federal officials came to a consensus that the government needed to embrace the approach now.

  13. https://www.nytimes.com/2022/08/03/us/politics/monkeypox-vaccine-doses-us.html

    U.S. Could Have Had Many More Doses of Monkeypox Vaccine This Year

    The Department of Health and Human Services delayed asking the manufacturer to process the bulk vaccine the government already owned into vials.
     

    By Sharon LaFraniereNoah Weiland and Joseph Goldstein

    Aug. 3, 2022

    WASHINGTON — The shortage of vaccines to combat a fast-growing monkeypox outbreak was caused in part because the Department of Health and Human Services failed early on to ask that bulk stocks of the vaccine it already owned be bottled for distribution, according to multiple administration officials familiar with the matter.

    By the time the federal government placed its orders, the vaccine’s Denmark-based manufacturer, Bavarian Nordic, had booked other clients and was unable to do the work for months, officials said — even though the federal government had invested well over $1 billion in the vaccine’s development.

    The government is now distributing about 1.1 million doses, less than a third of the 3.5 million that health officials now estimate are needed to fight the outbreak. It does not expect the next delivery, of half a million doses, until October. Most of the other 5.5 million doses the United States has ordered are not scheduled to be delivered until next year, according to the federal health agency.

    To speed up deliveries, the government is scrambling to find another firm to take over some of the bottling, capping and labeling of frozen bulk vaccine that is being stored in large plastic bags at Bavarian Nordic’s headquarters outside Copenhagen. Because that final manufacturing phase, known as fill and finish, is highly specialized, experts estimate it will take another company at least three months to gear up. Negotiations are ongoing with Grand River Aseptic Manufacturing, a Michigan factory that has helped produce Covid-19 vaccines, to bottle 2.5 million of the doses now on order, hopefully shaving months off the timetable, according to people familiar with the situation.

    Health and Human Services officials so miscalculated the need that on May 23, they allowed Bavarian Nordic to deliver about 215,000 fully finished doses that the federal government had already bought to European countries instead of holding them for the United States.

    At the time, the nation had only eight confirmed monkeypox cases, agency officials said. And it could not have used those doses immediately because the Food and Drug Administration had not yet certified the plant where the vaccine, Jynneos, was poured into vials.

    But it could now. Some states are trying to stretch out doses by giving recipients only one shot of the two-dose vaccine. California, Illinois and New York have declared public health emergencies. In New York City, every available slot for a monkeypox shot is taken.

    Lawrence O. Gostin, a former adviser to the Centers for Disease Control and Prevention who has consulted with the White House about monkeypox, said the government’s response has been hobbled by “the same kinds of bureaucratic delays and forgetfulness and dropping the ball that we did during the Covid pandemic.”

    The obstacles to filling and finishing vials follow other missteps that have limited vaccine supply. The United States once had some 20 million doses in a national stockpile but failed to replenish them as they expired, letting the supply dwindle to almost nothing. It had 372,000 doses ready to go in Denmark but waited weeks after the first case was identified in mid-May before requesting the delivery of most of those doses. Another roughly 786,000 doses were held up by an F.D.A. inspection of the manufacturer’s new fill-and-finish plant but have now been shipped.

    The government also owns the equivalent of about 16.5 million doses of bulk vaccine produced and stored by Bavarian Nordic. But by the time the health agency ordered 500,000 doses worth to be vialed on June 10, other countries with outbreaks had submitted their own orders and the earliest delivery date was October.

    Another order for 110,000 doses for European nations soon followed. When the United States came back with two more orders of 2.5 million doses each on July 1 and July 15, the bulk could only be delivered next year.

    Mr. Gostin, who now directs the O’Neill Institute for National and Global Health Law at Georgetown University, predicted that President Biden’s decision to appoint two new monkeypox response coordinators would help “light a fire” under federal health agencies. The White House announced Tuesday that Robert Fenton, an administrator at the Federal Emergency Management Agency, and Dr. Demetre Daskalakis, a C.D.C. official, will lead the response.

    Mr. Gostin said the nation’s public health agencies have been “kind of asleep at the wheel on this,” and the new coordinators should help with “unblocking all of the obstacles to procuring and delivering vaccines and drugs, which has been deeply frustrating.”

    Two senior federal officials, who requested anonymity in order to speak frankly, said Mr. Biden is upset by the vaccine shortage. His administration has often touted its success delivering hundreds of millions of coronavirus shots to Americans, and is stung by criticism that a lack of foresight and management has left gay men — the prime risk group for monkeypox — unprotected.

    Some critics blame a failure of leadership at the Health and Human Services Department, saying the department’s secretary, Xavier Becerra, has taken a hands-off approach to an increasingly serious situation. His department not only oversees both the C.D.C. and the Food and Drug Administration, but also runs the Biomedical Advanced Research and Development Authority, or BARDA, which helps develop and buys vaccines, tests and treatments to protect against highly contagious viruses, bioterrorism and other hazards.

    During a press call on monkeypox last week, Mr. Becerra said his department is doing all it can to ensure that “we not only stay ahead of this virus but that we end this outbreak.” He noted that he had recently elevated the agency’s Office of Strategic Preparedness and Response so it can respond more quickly to public health emergencies.

    Sarah Lovenheim, the department’s chief spokeswoman, said in a statement: “Our response has accelerated to meet evolving needs on the ground, and it will keep accelerating. We will use every lever possible to continue allocating doses ahead of timelines, as possible.”

    So far, according to the C.D.C., 6,326 cases of monkeypox have been reported. For now, the virus is spreading almost entirely among gay and bisexual men, and those with multiple or anonymous partners are considered especially at risk. Mr. Becerra noted that while more than a million Americans have died of Covid-19, no one in the United States has died of monkeypox.

    The official case count is widely considered an underestimate. Not only is testing limited, but public health officials like Dr. Joseph Kanter, the top medical official in Louisiana, said that monkeypox can be hard to diagnose. “It can be one or two solitary lesions, so if it’s not on a clinician’s radar,” he said, it can be missed.

    With too few doses, health officials apparently plan to rely heavily on the “test and trace” strategy that figured heavily in the early stages of the Covid pandemic. As the pandemic escalated, the sheer torrent of cases overwhelmed the ability of health officials to contact people who might have been infected by someone who had tested positive for the coronavirus. Once Covid vaccines became available, they became the cornerstone of the administration’s pandemic response.

    Through early June, Health and Human Services officials appeared firmly convinced that the United States had more than enough supply of the monkeypox vaccine, called Jynneos, to handle what appeared to be a handful of cases.

    Bavarian Nordic was able to develop the vaccine, which also works against smallpox, largely thanks to the federal government’s backing, which surpassed $1 billion in 2014 and is now edging toward $2 billion. Dawn O’Connell, the federal health agency’s assistant secretary for preparedness and response, told reporters in early June: “The world has Jynneos because we invested in it.”

    The company opened a new $75 million fill-and-finish plant in 2021 that is now bottling as many as 200,000 to 300,000 doses a week. At the time, the United States was counting on Jynneos to protect against smallpox, not monkeypox, and the government had a large stockpile of another effective smallpox vaccine. No F.D.A. inspection was scheduled until after the monkeypox outbreak, and it did not conclude until July 27.

    In early June, Health and Human Services officials agreed to essentially loan back about 215,000 finished doses of vaccine to Bavarian Nordic so the firm could supply them to European countries that were suffering outbreaks.

    “It didn’t make sense while we were waiting for F.D.A. to get the inspection done — which is coming — that we sit on doses that our international colleagues in Europe could actually use,” Ms. O’Connell said on June 10. Now the government is trying to reschedule delivery of those doses for later this year, a company spokesman said.

    The final stage of putting the liquid vaccine into vials accounts for a substantial share of the cost of vaccine production. Some federal officials say the health department was slow to submit its orders for that work because officials at BARDA argued they were short on funds.

    When the demand for vaccines became an outcry, though, the agency found the money to pay for five million more doses to be vialed. Officials are now contemplating shifting half the work to another firm that may be able to finish and fill doses more than twice as fast.

    Some experts say it can take as long as six to nine months for a plant to gear up to handle a vaccine like Jynneos, which contains a live virus in a weakened state. Carlo de Notaristefani, who oversaw coronavirus vaccine manufacturing for the federal government until last year, said that such factories must operate at a high “biological safety level,” including a fully enclosed, segregated manufacturing line.

    But he and other experts said it should be possible to streamline the transfer of Bavarian Nordic’s process so another plant could be ready in about three months. A company spokesperson said Bavarian Nordic agreed to pay $10 million of the cost of such a transfer after federal officials said they did not have the budget for it.

    Kitty Bennett contributed research.

  14. 46 minutes ago, tassojunior said:

    Just what we need after HIV and Covid. Another reason to not have sex. No wonder so few guys are getting into the business. If you thought the CDC was over the top on masks and covid, here's their "Don't Have Sex!" MonkeyPox advice:

    https://www.cdc.gov/poxvirus/monkeypox/sexualhealth/index.html

     

    Hardly over the top to advise against having sex if one knows or suspects that oneself or one’s prospective partner has monkeypox?

  15. 30 minutes ago, tassojunior said:

    The rationale is that fighting proxy wars may cost a lot (all US wars do) but they weaken adversaries to American hegemony without costing American lives, which is politically costly. 

    Or maybe they really do want all-out war. When even Kissinger says you're pro-war crazy, you're past lunatic. Pelosi unnecessarily being sent to Taiwan just to stir up conflict fits that theory.

    I would not credit Biden with that kind of 4D chess thinking. Perhaps if we had a leader like Xi or Putin who was thinking in decades and did not have the inconvenience of elections, he could afford to take such a long view. As it stands though Biden's party is about to get trounced in the midterms and he himself does not need any further foreign policy disasters on his hands if he runs for re-election in 2024. 

    It's also a bit too much to think that Pelosi is secretly there at Biden's behest despite his public messages otherwise. Her going against his protestations just makes Biden look weak and feckless that he can't rein in a Speaker of his own party from needlessly provoking China when we are already in a proxy war with Russia. Further, Biden publicly pleading with her not to go just emboldened the Chinese to further harden their stance and rhetoric against her trip, thinking such pressure could perhaps be effective if even Biden was urging against the trip. Making it more difficult for Pelosi to back out as doing so would just encourage and reward more of the same behavior from Beijing in the future. 

    Which is why Biden should have kept his concerns private. Perhaps Pelosi might have listened to a private plea if publicly it could still look like she was calling the shots.

  16. 3 minutes ago, PeterRS said:

    How likely is this to happen again in the 2020s if another airline goes bust?

    I wouldn't lose too much sleep over this possibility. Avianca recently declared bankruptcy and emerged from restructuring in December 2021. Frequent flyer members were unaffected throughout the process. FFP programs have matured a lot since 2002 and would likely be viewed as an asset to be preserved during the BK process because they are generally great revenue machines for the airline (in the case of Avianca especially so because they are very prolific in selling miles, as @fedssocr can attest!). Zeroing out FFP members' balances would destroy a lot of intangible "goodwill" value for a creditor -- likely much more so than whatever the book value of the miles' liability.

    That said - anything is possible of course! Don't build up hundreds of thousands of miles with an airline without any particular redemption plan and remain oblivious to their financial fortunes...

    One other possibility though is mergers/acquisitions. It looks like Asiana Airlines is going to be acquired by Korean Air. Asiana is currently a Star Alliance member and has some of the best deals in the miles game -- for example, 35,000 miles one-way between the US and Brazil in business class. I have about 70,000 miles with them that I'm looking for opportunities to use on Brazil tickets before the merger goes through, because I imagine they will be converted to Korean (SkyTeam) miles at some point.

  17. 1 hour ago, fedssocr said:

    I guess I never considered Asia Miles - never used that program. Thanks for that tip. I had about 100K AA and had to buy the difference to have enough for this ticket. I have a lot of Amex points and have spent most of my Citi points. I have a big stash of Avianca miles that I bought a while ago. Unfortunately they don't seem to have many available award seats these days. I'm hoping that will improve once things get more back to normal.

    Lifemiles has a notoriously bad search engine that may be contributing to the lack of available seating you are finding if the itinerary is at all complex (2+ segments). If you can find it available on Aeroplan or another Star Alliance carrier, try searching for it segment-by-segment on Lifemiles (specifying the specific airline as well as “Star Alliance” if you don’t initially see it) and email them for a manual booking if you can find the individual flights, using the process outlined here: https://frequentmiler.com/when-lifemiles-com-shows-no-availability-try-a-manual-booking/

    I imagine you’ll want to burn your Lifemiles before dipping into AmEx points, but for future travel to Bangkok one other avenue you might want to explore is ANA’s “around the world” ticket. You could fly IAD-NRT on ANA/United, NRT-BKK on ANA/Thai, BKK-FRA on Thai/Lufthansa, and FRA-IAD on Lufthansa/United all for 115,000 ANA miles in business class. https://www.ana.co.jp/en/us/amc/partner-flight-awards/around-the-world/

    I love helping to put award itineraries together so feel free to DM next time you are booking a trip 😀 

  18. 7 minutes ago, forrestreid said:

    We will await with interest whether she does turn up in Taiwan, or follows the Biden counsel to stay away.

     

    She just announced today that the visit to Taiwan will proceed.

    I think Biden erred in publicly weighing in at all on the visit - the best thing would have been from the beginning to just state that Congress is an independent, coequal branch of government whose members do not need the permission or blessing of the President to travel where they wish — and such travel has no bearing on the Administration’s foreign policy.

  19. 2 hours ago, fedssocr said:

    AA's routing rules are annoying. My recently booked IAD-DOH-BKK itinerary on QR was reservable on the AA website, but was not bookable without calling them to complete the transaction. It was pretty straightforward though. Since the booking was already in the system the AAgent just had to complete the process so it was a short call. Since it's two award it cost me 110K miles.

    Do you have access to a stash of Asia Miles? They would have charged 90k miles for the same ticket (I'm assuming in business class at that price with AA?). They are transfer partners with Amex, Citi and Capital One. 

    I certainly value AA miles more dearly than Amex points so let me know if you ever want to make a trade 😉

  20. On 7/30/2022 at 2:15 AM, alvnv said:

    Yes, a few years ago I had to call AA to book award flights on QR, but anymore it’s available online. However, there are strange rules in place when it comes to certain city pairs, e.g. there are no award seats between NYC-DOH-BKK, but there are plenty between NYC-DOH and LHR-DOH-BKK. The only options using AA between DOH and BKK is a connection through Sri Lanka. Meanwhile, award seats are available on both NYC-DOH-BKK and DOH-BKK flights using BA.

    Ah I stand corrected about the booking of QR flights online with AA. Still, it may have been possible to book the flights by calling up a phone agent even if the online booking had temporarily disappeared.

    Regarding NYC-DOH-BKK, that would not be allowed as a single award ticket with AA miles because their routing rules require transpacific travel between the USA and Asia (with the exception of the Indian subcontinent, in which case it must be TATL unless via Hong Kong). It doesn't make a ton of sense in cases like this, where JFK-DOH-BKK is less than a 5% differential in terms of total miles compared to say JFK-NRT-BKK. But I could understand AA frowning on say LAX-DOH-BKK rather than via HKG or NRT.
     

     

    On 7/30/2022 at 2:44 AM, PeterRS said:

    I take all your points. I'll only again request a response to the issue about ExpertFlyer before I take out  subscription. Does it give details of mileage seats available on all airlines in a certain Alliance on a certain date or series of dates? Specifically, does it differentiate between those seats only available to loyalty members of the issuing airline before they become available to others?

    Apologies for the delay responding on this. ExpertFlyer isn't doing me any favors helping them market because their QR search capabilities are non-functional at the moment! According to their representative at FlyerTalk, it is being worked on. Still, it's possible to search their availability using other OneWorld airlines such as BA.

    Generally though, they don't allow single searches that would check all airlines in a given alliance. You have to search by individual airline and route. Still, there are some exceptions in terms of airlines that aren't covered - Cathay Pacific for one (although if one is merely using Asia Miles to book award on another OneWorld airline, the data is still useful because the relevant question is whether the operating airline has released an award seat on the flight you want).

    Regarding differentiation between various awards -- it depends on the airline in question but generally it allows basic searches for award seats that are open to all other airlines in an alliance. Some airlines allow you to search for additional award type inventory, such as seats that are only open to elite fliers or seats that are bookable with upgrade instruments.

    ExpertFlyer offers a free five day trial to their premium service is you want to try it out. I'd recommend waiting until you have another trip to book/plan. Happy to answer any additional questions you may have about their service.

     

    On 7/30/2022 at 2:44 AM, PeterRS said:

    It seems they do train their agents well and to date I have not had any major issue with them re detail.

    I will take your word for it - I have only booked a handful of Asia Miles awards in my life and generally didn't have issues, but I did make sure I knew that what I wanted was bookable before calling. There is one exception that comes to mind: I was returning from Brazil on AA, GRU-JFK-DCA, with the last leg being an American Eagle flight (AA's regional brand) that was "operated by Republic Airways for American Eagle". I had originally booked the itinerary with Asia Miles and was calling to make a date change. The first several agents claimed it couldn't be booked because Republic Airways wasn't part of OneWorld and they didn't have access to their award inventory (I knew this to be false; American Eagle flights are made bookable to all OneWorld partners by AA if/when they decide to release seats on them). I had to call and hang up several times before I found an agent who would do the date change - after I pointed out that it had to be possible, because they had booked that same flight for me on a different date originally.

    All that to say - my main point is just that it's always a good idea to know at least as much about what an airline representative can do for you as they do before getting on the phone with them. This goes doubly so for things like irregular operations where you need to be re-accommodated on another flight due to a weather cancelation or a known future misconnect due to delay at point of departure. As soon as you learn you'll need your flights changed, figure out what's available and call them up. Don't wait in line for the airport agent to finally get to you - by which point perhaps the seats on the most optimal re-routing have already been snatched by other passengers.

     

  21. 6 minutes ago, alvnv said:

    QR is notorious for challenges with award seats (or, even $$ tickets) through their codeshare, OneWorld and other partners. The only exception is BA. I was able to find award seats on QR through BA quite easily when AA did not have any availability for the same dates/cities. BA and AA also have strange rules when allocating award seats for each other’s FF programs for the city pairs that they both serve.

    I'm not sure this is still the case, but at least in the past QR flights couldn't be booked online with AA. You have/had to call in (see https://upgradedpoints.com/travel/airlines/best-ways-to-book-qatar-qsuites-with-points-and-miles/, scroll down to the section on using American miles to book).

    Now that Qatar is using Avios as its award inventory though, it's possible that BA would have access to flights that other, non-Avios OneWorld partners would not.

    Typically partner availability is an all-or-nothing thing, but sometimes when airlines in an alliance have an especially close relationship they do make inventory available to those partners that isn't available alliance-wide. Usually when you see that though, it's because they are making the "award" available on a dynamic price basis that is a lot higher than a standard saver award. Thus for example, you'll often see very high mileage Copa tickets available through United MileagePlus where the same Copa ticket wouldn't show up at all if searching on Air Canada. Or ditto with Alaska/American having higher priced tickets that an Asia Miles agent wouldn't be able to book.

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